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Computer-aided Geometric Design

RRP $519.99

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Computer graphics, computer-aided design, and computer-aided manufacturing are tools that have become indispensable to a wide array of activities in contemporary society. Euclidean processing provides the basis for these computer-aided design systems although it contains elements that inevitably lead to an inaccurate, non-robust, and complex system. The primary cause of the deficiencies of Euclidean processing is the division operation, which becomes necessary if an n-space problem is to be processed in n-space. The difficulties that accompany the division operation may be avoided if processing is conducted entirely in (n+1)-space. The paradigm attained through the logical extension of this approach, totally four-dimensional processing, is the subject of this book. This book offers a new system of geometric processing techniques that attain accurate, robust, and compact computations, and allow the construction of a systematically structured CAD system.

Role Of Dna Damage And Repair In Cell Aging

RRP $34.99

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Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear," with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging.

As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters.

This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.

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