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Computer graphics, computer-aided design, and computer-aided manufacturing are tools that have become indispensable to a wide array of activities in contemporary society. Euclidean processing provides the basis for these computer-aided design systems although it contains elements that inevitably lead to an inaccurate, non-robust, and complex system. The primary cause of the deficiencies of Euclidean processing is the division operation, which becomes necessary if an n-space problem is to be processed in n-space. The difficulties that accompany the division operation may be avoided if processing is conducted entirely in (n+1)-space. The paradigm attained through the logical extension of this approach, totally four-dimensional processing, is the subject of this book. This book offers a new system of geometric processing techniques that attain accurate, robust, and compact computations, and allow the construction of a systematically structured CAD system.
Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear," with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging.
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